2004.04.28 13:46 "[Tiff] Reading and writing 3D tiff images", by Peter Van Osta

2004.04.30 08:21 "Re: [Tiff] multipage TIFFs source code", by Kai-Uwe Behrmann

Look at <http://libtiff.org/libtiff.html#Dirs> for basic Directory handling. There are more explanations on this site.

You may use cinepaint for opening and writing multipage tiffs. The depth of 16-bit per channel will be preserved. <http://cinepaint.sf.net>

I think <http://www.graphicsmagick.org/> will as well be able to do multipage tiff i/o with 16-bit/channel data.

Both applications are open source.